Make feeling good part of your day, every day.

Helps Support A Healthy Mood & Emotional Wellbeing

A healthy mood sets the tone for your whole day. Sometimes emotions can get out of balance, causing you to feel moody. This imbalance can be associated with low levels of SAM-e (S-adenosylmethionine), which can be due to various factors such as diet and aging. Learn more to see if SAM-e is right for you.

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Understanding SAM-e Supplements

Clinically studied SAM-e. Replenish your SAM-e levels and feel the difference in as little as 7–14 days when taken daily.

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What is SAM-e?

SAM-e (s-adenosylmethionine) is a molecule in our bodies that may increase levels of neurotransmitters, or brain chemicals, responsible for mood. SAM-e provides a source of sulfur, which is a critical component of joint tissue.†

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Who should take SAM-e?

Glad you asked. SAM-e levels can run low due to various factors such as diet and aging.†

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What is SAM-e good for?

Nature Made® SAM-e Complete® can help to replenish your SAM-e levels and restore your healthy mood in as little as 7–14 days when taken daily. However, if you are experiencing symptoms of a low mood, see a physician for a proper guidance. SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age.†


Explore expert answers to some of the most frequently asked SAM-e questions.

  • Why take SAM-e?

    Nature Made® SAM-e Complete♦ products help support a healthy mood and joint comfort. SAM-e also has other vital functions aside from helping to support a healthy mood. One of these other functions is helping to support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e also provides a source of sulfur—an essential component of joint tissue.
  • How much SAM-e should I take daily?

    You should start out with 400 mg of SAM-e every day. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1,600 mg/day) and consult with your doctor until you begin to experience the desired benefits.
  • How long will SAM-e take to work?

    Many people report mood improvement in as little as one to two weeks. If after 2 weeks you are not experiencing desired benefits, you may want to try gradually increasing the dose after consulting with your doctor. If you're taking SAM-e for your joints, you may have to wait up to a month to experience results.
  • How long should I keep taking SAM-e?

    SAM-e supplements may be taken on a daily basis. SAM-e can be used daily to benefit mood and support joint health. So you can continue taking SAM-e as long as you are not experiencing any adverse effects and experience results. If you have any concerns or have changes in your medications, please consult your doctor.
  • When does this product expire?

    Please refer to the expiration date on the bottle.