Nature Made® SAM-e Complete 400mg surrounded by sunflowers

SAM-e Supplements

Make feeling good part of your day, every day.

SAM-e Supplements

Supports a positive mood and emotional wellbeing.^†

SAM-e Supplements

Make feeling good part of your day, every day.

SAM-e Complete^®◆

4.22 average rating out of 5. Has 9 reviews.

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TABLET

400 mg

$62.19

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SAM-e Complete^®◆

4.43 average rating out of 5. Has 7 reviews.

TABLET

200 mg

$62.19

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Understanding SAM-e Supplements

Clinically studied SAM-e. Replenish your SAM-e levels, feel the difference in as little as 7–14 days when taken daily.^†

What is SAM-e?

SAM-e (s-adenosylmethionine) is a molecule in our bodies that may increase levels of neurotransmitters, or brain chemicals, responsible for mood. SAM-e provides a source of...

Who should take SAM-e?

Any adult looking to support their SAM-e levels. SAM-e levels can run low due to various factors such as diet and aging. SAM-e supplementation can...

What is SAM-e good for?

SAM-e supports a positive mood and emotional well-being and helps restore a healthy mood in as little as 7 to 14 days when taken daily....

SAM-e Supplement FAQs EXPLORE FAQS Explore FAQs on SAM-e Supplement FAQs

Explore expert answers to some of the most frequently asked SAM-e questions.

Nature Made^{^®} SAM-e Complete^♦ products help support a positive mood and emotional wellbeing. SAM-e also has other important functions aside from helping to support a healthy mood; one of these other functions is helping to support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e also provides a source of sulfur—an essential component of joint tissue. SAM-e is made in the body from methionine, an amino acid found in foods like fish, beef, and nuts, but there is no direct dietary source of SAM-e.^{^†}
You should start out with 400 mg of SAM-e every day. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, speak to a healthcare professional. You may gradually increase the number of tablets (maximum 1,600 mg/day) until you begin to experience the desired benefits; consulting your doctor can help you determine the best dosage.
SAM-e can help restore a healthy mood in as little as 7 to 14 days when taken daily. If, after 2 weeks, you are not experiencing desired benefits, you may want to try gradually increasing the dose after consulting with your primary care provider. If you're taking SAM-e for your joints, you may have to wait up to a month to experience results.^{^†}
SAM-e supplements may be taken on a daily basis to support a positive mood and joint comfort. If benefits are not achieved within two weeks, you may require a higher level of supplementation. Consult with a doctor to help determine the best dosage. People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM-e except under a physician's supervision. If you are pregnant, nursing, or taking any medications including antidepressants, consult your physician before use.^{^†}
SAM-e can be safely integrated into your everyday wellness routine alongside other vitamins and minerals. Consult with your healthcare provider before starting or changing your supplement routine, for personalized advice and guidance.

People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM- except under a physician’s supervision. If you are pregnant, nursing, or taking any medications including antidepressants, consult your physician before use.
Nature Made^{^®} offers numerous supplements in addition to SAM-e that support joint health, including:
- Turmeric: Supports a healthy inflammation response from daily activity.^{^†}
- Glucosamine Hydrochloride: A natural compound that is a building block for cartilage. Cartilage helps maintain the structural integrity you need for healthy joints.^{^†}
- Collagen Peptides Powder: Our Collagen drink mix powder includes a clinically studied ingredient that supports healthy joints and joint comfort to help support your active lifestyle. ^▴ ^▪ ^{^†}
To explore other supplements for mood, consider:
- Vitamin B6: Supports production of SAM-e, which is important to mood health.^{^†}
- Vitamin B12: Adequate Vitamin B12 status helps support a healthy mood.^{^†}
- Choline: Helps make acetylcholine to support memory and mood.^{^†}
- 5-HTP: Helps make serotonin to support mood health and wellbeing.^{^†}
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EXPLORE FAQS

Supports a positive mood and emotional wellbeing.^†

SAM-e Supplement Facts

Nature Made^® offers clinically studied SAM-e to naturally support a positive mood and emotional wellbeing. Replenish your SAM-e levels and feel the difference in as little as 7-14 days when taken daily. SAM-e is important to neurotransmitter function and mood health, and SAM-e and methylation levels decrease with aging. Shop Nature Made^®’s SAM-e supplements today.^†

♦ Complete because studies have shown that SAM-e helps support a healthy mood and joint comfort.^†

▴In active young adults.

▪Blend consists of two collagen peptide ingredients.

* Based on a survey of pharmacists who recommend branded vitamins and supplements

† These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References

Toguchi, A., Noguchi, N., Kanno, T., & Yamada, A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 15(13), 2995. June 30, 2023. https://doi.org/10.3390/nu15132995. Accessed on November 5, 2024.
S-Adenosyl-L-Methionine (SAMe): In Depth. National Center for Complementary and Integrative Health (NCCIH). January 2017. https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth. Accessed on November 5, 2024.

SAM-e Supplements

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Supporting a Healthy Mood

A Proactive Approach to Long-Term Joint Health

Looking for Triple Flex? Find Joint Support with SAM-e^†

Understanding SAM-e Supplements

What is SAM-e?

Who should take SAM-e?

What is SAM-e good for?

SAM-e Supplement FAQs EXPLORE FAQS Explore FAQs on SAM-e Supplement FAQs

Why take SAM-e?

How much SAM-e should I take daily?

How long will SAM-e take to work?

How long should I keep taking SAM-e?

How does SAM-e help with joints?

Can I take SAM-e with other supplements?

What other supplements support joint health?

What other supplements can support mood?

SAM-e Supplement Facts

References

SAM-e Supplements

SAM-e Supplements

SAM-e Supplements

Make feeling good part of your day, every day.

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Want to know more?

Supporting a Healthy Mood

A Proactive Approach to Long-Term Joint Health

Looking for Triple Flex? Find Joint Support with SAM-e†

Understanding SAM-e Supplements

What is SAM-e?

Who should take SAM-e?

What is SAM-e good for?

SAM-e Supplement FAQs EXPLORE FAQS Explore FAQs on SAM-e Supplement FAQs

Why take SAM-e?

How much SAM-e should I take daily?

How long will SAM-e take to work?

How long should I keep taking SAM-e?

How does SAM-e help with joints?

Can I take SAM-e with other supplements?

What other supplements support joint health?

What other supplements can support mood?

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SAM-e Supplement Facts

References

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Looking for Triple Flex? Find Joint Support with SAM-e^†