Looking for Triple Flex? Find Joint Support with SAM-e

Jun 03, 2022 Joint Health 3 MIN

Looking for Triple Flex? Find Joint Support with SAM-e<sup>†</sup>

Quick Health Scoop

  • If you’re looking for a Nature Made® joint support supplement, then you might want to consider SAM-e.
  • SAM-e is a naturally occurring molecule made in the cells of our bodies.
  • SAM-e helps support joint comfort, which may naturally deteriorate with physical activity and age.
  • SAM-e also helps support a healthy mood and emotional wellbeing.

You might be here because you’re looking for a way to support your joints now that Nature Made® Triple Flex® has been discontinued. Never fear! Nature Made still has supplements that help support joint comfort.


Triple down on joint support† with Glucosamine Chondroitin


Also, if you’ve never heard of SAM-e or of the benefits of supplementing with this compound, then read on!

SAM-e (S-adenosylmethionine) is a naturally occurring molecule that is made in our cells. This compound was first discovered in the 1950s and was studied for its effect on people’s moods as well as for the compound’s effect on joint function [1]. SAM-e provides a source of sulfur, which is a critical component of joint tissue.

So why take a SAM-e supplement? SAM-e has been clinically studied to help support a healthy mood, and it also helps support joint comfort. However, natural levels can run low due to aging and diet. You can help supplement your SAM-e levels by eating foods that contain the amino acid methionine or taking a SAM-e dietary supplement.

Learn More: What Vitamins Should Women Take Daily?


How Do I Take SAM-e?

There are no direct dietary sources for SAM-e, as it is produced naturally in the body. However, the body uses the amino acid methionine to produce SAM-e. Increasing your intake of this amino acid may help increase SAM-e production [2]. Methionine can be found in protein-rich foods such as red meat, fish, turkey, eggs, nuts, and beans.

In addition to foods that contain methionine, you can obtain SAM-e from dietary supplements, such as Nature Made® SAM-e Complete®. When taking a SAM-e supplement, it is suggested to start taking 400 mg a day with water on an empty stomach. If you are taking SAM-e to support your mood, and its benefits are not achieved within two weeks, then you might need a higher level of supplementation. The number of tablets should increase gradually and not exceed a maximum of 1600 mg per day. If you are supplementing SAM-e to support your joints, it may take up to a month to feel any benefits. If you feel you need to increase your supplementation, it is best to consult with your healthcare provider.

Learn More: What Vitamins Should Men Take Daily?


How Else Can I Support My Joints?

Great question! As we age, supporting our joints becomes more and more important. The best option to support your joints is to get moving. Exercise, even just a small amount daily, can help keep your muscles active and even improve your mood. For the most benefit, balance aerobic activity with flexibility exercises, such as yoga, as well as muscle strengthening exercises. Strengthening your muscles will help reduce the load on your joints. Walking, bicycling and swimming are great low-intensity options to keep your joints regularly moving while being supported [3]. The best answer is to keep moving in whatever way feels best for you!

Learn More: Answer the Call to Exercise!


The Bottom Line

Even though Nature Made® no longer carries the Triple Flex® Glucosamine, Chondroitin, and MSM supplement, a SAM-e supplement may meet your joint health needs and additionally help support a healthy mood. Because a SAM-e supplement may interfere with some medications and other dietary supplements, make sure to consult with a healthcare provider about your needs and if you should take a SAM-e supplement, such as Nature Made® SAM-e Complete® in either 200 mg or 400 mg tablets. 


Learn More About Bone, Skin & Tissue Health:


♦Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort.

† These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


  1. “S-Adenosyl-L-Methionine (SAMe): In Depth.” National Center for Complementary and Integrative Health, U.S. Department of Health and Human Services, https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth.
  2. Bottiglieri, Teodoro. “S-Adenosyl-L-Methionine (Same): From the Bench to the Bedside-Molecular Basis of a Pleiotrophic Molecule.” OUP Academic, Oxford University Press, 1 Nov. 2002, https://academic.oup.com/ajcn/article/76/5/1151S/4824259.
  3. Bone, Muscle and Joint Team. “The Best Exercises to Keep Your Joints Healthy.” Cleveland Clinic, Cleveland Clinic, 11 Mar. 2022, https://health.clevelandclinic.org/how-to-keep-your-joints-healthy-with-the-right-exercise/.


Amy Mills Klipstine

NatureMade Sr. Copywriter

Amy has an MFA in Creative Writing from Antioch University in Los Angeles and is a credentialed English teacher, though she left the classroom to write full time. She especially enjoys creating educational content about health, wellness, and nutrition. Her happy place is in the kitchen, and when not writing, you can find her trying out “kid-friendly recipes” and “healthy desserts for chocolate lovers” from her Pinterest board.

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Sandra Zagorin, MS, RD

Science and Health Educator

As a member of the Medical and Scientific Communications team, Sandra educates healthcare professionals and consumers on nutrition, supplements, and related health concerns. Prior to joining Pharmavite, Sandra worked as a clinical dietitian at University of Chicago Medicine in the inpatient and outpatient settings. Sandra received her Bachelor of Science degree in Nutritional Science, with minors in Spanish and Chemistry from the University of Arizona in Tucson, AZ. She earned her Master of Science degree in Clinical Nutrition from RUSH University in Chicago, IL. As part of her Master’s program, Sandra performed research on physical activity participation and correlates in urban Hispanic women.

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