Nature Made® product formulas may change from time to time. Please consult the label on the product that you purchased for product composition information.

TripleFlex Triple Strength


Nature Made TripleFlex Triple Strength is a blend of three key ingredients to help keep your joints healthy in two caplets daily.

  • Glucosamine helps support healthy cartilage
  • Chondroitin helps provide a cushion for joints, and MSM helps to support joint strength and flexibility
2 Daily

Product Details

In the News: Nature Made® TripleFlex® Triple Strength*. Read More

Original Formula Nature Made TripleFlex® Triple Strength* provides ingredients that help to support overall joint health and comfort. Nature Made TripleFlex Triple Strength* is a combination of three ingredients to help support joint health with two caplets daily. Glucosamine helps to support joint comfort, mobility and flexibility. Chondroitin helps support joint lubrication and cushioning that helps support joint flexibility, and MSM provides a source of sulfur, a mineral used by the body in collagen, connective tissue and joint cartilage. Contains glucosamine hydrochloride (1500 mg), chondroitin sulfate (800 mg) and MSM (750 mg) per two caplets.

  • Helps replenish key nutrients needed for daily joint support

Nature Made TripleFlex Triple Strength Glucosamine Chondroitin MSM is guaranteed to meet our high quality standards – it is made from carefully selected ingredients under strict manufacturing processes.

  • No Artificial Flavors
  • No Preservatives
  • No Yeast or Gluten

* 2 caplet per day formula.

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Dosage and Interactions

When to Take:

SUGGESTED USE: Take two caplets daily, with food. Caplets can be taken together or at different times during the day. For easier swallowing, take with water before and during ingestion.


Triple Flex Triple Strength should be used with caution when combined with:

  • Blood thinning medication (e.g. Warfarin and Coumadin)
  • Anti-diabetic drugs
  • Anti-neoplastic drugs
  • Nonsteroidal anti-inflammatory drugs (e.g. ibuprofen and aspirin)

Caution: Not for use by children or teenagers. Do not use if you are allergic or sensitive to aspirin or shellfish. If you are taking blood thinning or other medications, consult your health care professional before using this product. Discontinue use two weeks prior to surgery, or if upset stomach occurs. If you are pregnant or nursing, consult your health care professional before taking this product.

Given that no two people are alike, if you are taking any medications you should be aware that potential drug-nutrient interactions may occur and are encouraged to consult a health care professional before using this product.  Combining certain prescription drugs and dietary supplements can lead to undesirable effects such as:

  • Diminished drug effectiveness
  • Reduced supplement effectiveness
  • Impaired drug and/or supplement absorption


Are there any side effects to taking Glucosamine?

The side effects to taking Glucosamine may include gastrointestinal symptoms, drowsiness, headache, and skin rash. Individuals who are allergic to shellfish should use caution with glucosamine and check with their health care provider.

How long does it take to feel effects?

When taking glucosamine and chondroitin, many people begin to feel support in 4-6 weeks on average when taken daily. Individual results may vary.

If I am diabetic, can I use Glucosamine?

If you have diabetes, we suggest that you consult your physician before using. In those with diabetes, glucosamine supplementation can potentially affect one’s blood sugar/glucose level.

What is Glucosamine?

Glucosamine is a natural substance in joints, which plays a role in the building up of cartilage.†

What is Glucosamine made from?

Glucosamine is made from crab shell (chitin).


For 40 years, we have been obsessed with quality at Nature Made®. From ingredient sourcing, to industry-leading manufacturing practices, to our third-party verification approach, we believe it is our responsibility to lead in delivering quality products and a quality consumer experience. For more information, click here.