• Nature Made CholestOff Plus
  • Nature Made CholestOff Plus
  • Nature Made CholestOff

CholestOff® Plus

Liquid Softgels

CholestOff® Plus is clinically proven to lower cholesterol.

  • A proprietary blend of plant sterols and stanols that can help lower LDL (“bad”) cholesterol

Product Details

A healthy cholesterol level is important for good heart health. CholestOff® Plus is made with Reducol, a proprietary blend of plant sterols and stanols (also called phytosterols) that can help lower LDL (“bad”) cholesterol by reducing the absorption of dietary cholesterol into the bloodstream.*

What Cholestoff® Plus Is.
CholestOff® Plus is formulated with esterified sterols and stanols instead of free form sterols and stanols in CholestOff® Original. The esterified sterols and stanols have been clinically proven to have cholesterol-lowering benefits. Additionally, Nature Made has conducted clinical trials examining the effects of CholestOff Plus on cholesterol. Our studies show that consuming CholestOff® Plus in addition to following the National Institutes of Health's National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet, reduced LDL cholesterol levels.*

How does it work?
The cholesterol-lowering effect of plant stanol/sterol esters occurs by “competition” between cholesterol and plant stanols for incorporation into mixed micelles in the intestine. This leads to a decrease in the amount of cholesterol absorbed into the bloodstream from the intestine. Therefore, less cholesterol then enters our circulation and less cholesterol is absorbed by our body.*

Nature Made CholestOff Plus

Why are plant sterols and stanols important?
Plant sterols and stanols are part of the NCEP TLC diet. The TLC diet recommends 2000 milligrams of plant sterols and stanols daily as part of a therapeutic diet to help lower cholesterol. This may be difficult to get just from the foods we eat since most people only consume about 200 milligrams of plant sterol and stanols through their diet. Taken twice daily with a meal, CholestOff® Plus provides the additional 1800 milligrams of plant sterols and stanols to help meet what the NCEP recommends for cholesterol reduction in an easy to swallow liquid softgel.*

Nature Made CholestOff® Plus is guaranteed to meet our high quality standards – it is made from carefully selected ingredients under strict manufacturing processes.

  • Colors Derived from Natural Sources – no synthetic dyes
  • No Artificial Flavors
  • No Preservatives
  • No Yeast or Starch
  • Gluten Free

*Products containing at least 400 mg per serving of plant sterols and Stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. One serving of CholestOff® Plus supplies 900 mg of plant sterols and stanols per serving for a daily intake of 1800 mg.

*Based on US News & World Report - Pharmacy Times Survey, Nature Made is the #1 Pharmacist Recommended Brand in Cholesterol Management-Natural.

Nature Made When to Take Your Vitamins

Dosage and Interactions


Take two softgels two times daily with a glass of water or other beverage at your largest meals.


CholestOff® Plus should be used with caution when combined with:

  • Statin drugs

Caution: Not for use by children or pregnant or lactating women.  Check with your physician before using CholestOff Plus if you are currently using medications to lower your cholesterol.

Given that no two people are alike, if you are taking any medications you should be aware that potential drug-nutrient interactions may occur and are encouraged to consult a health care professional before using this product.  Combining certain prescription drugs and dietary supplements can lead to undesirable effects such as:

  • Diminished drug effectiveness
  • Reduced supplement effectiveness
  • Impaired drug and/or supplement absorption


Do I take it before or after my meal?

We suggest that you take the product right before your meal.

How many times a day do I have to take CholestOff Plus?

We suggest taking it twice a day. Studies show that 1800 mg of plant sterols and stanols a day may help lower cholesterol. Therefore, the suggested use is to take 4 softgels a day (450 mg each), for a total of 1800 mg.

What is the source of gelatin in this product?

It is derived from porcine (pork).

What meals can I take CholestOff Plus with?

CholestOff Plus may be taken with any of your two largest meals, any time of the day. We suggest that you take CholestOff Plus with whichever meals may contain more cholesterol.


For 40 years, we have been obsessed with quality at Nature Made®. From ingredient sourcing, to industry-leading manufacturing practices, to our third-party verification approach, we believe it is our responsibility to lead in delivering quality products and a quality consumer experience. For more information, click here.